Nano Technology

NSRT is constantly thriving on development of novel drug delivery systems like vesicles (liposomes, niosomes, transfersomes, ethosomes), particulates (microspheres/particles, nanoparticles), micelles, emulsions (microemulsions, nanoemulsions, self-emulsifying systems), microneedles, etc.


  • High shear homogenizer (IKA)
  • High pressure homogenizer (Avestin)
  • Rotary evaporator with chiller (R12)
  • Probe sonicator (Hielscher)
  • Zetasizer (Delsa Max Pro, Beckman Coulter)
  • Lyophilizer (VirTisAdVantage)
  • Incubator shaker
  • Microscope
  • Centrifuge, etc.

Vesicular Formulation

Vesicular drug delivery system are highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water. Varying from size of few nanometers to few micrometers, these formulations are suitable for delivery through all routes of administration, like oral, injection, topical, transdermal, etc. Depending on the constituent of bilayer, they are given different names like Liposomes (bilayer of Phospholipids), Niosomes (non-ionic surfactants), flexible liposomes (phospholipid bilayer with edge activators), etc.

Salient features

  • Suitable for both hydrophilic and hydrophobic drugs.
  • Improve Bioavailability.
  • Delay elimination of rapidly metabolizable drug.
  • Prolonged circulation life in the body possible.
  • Targeted delivery through ligand-conjugation & modified surface properties.
  • Improve drug stability.
  • Reduce toxicity.
  • Flexible liposomes &niosomes improves permeability through tight junctions

Particulate Formulation

Particulate drug delivery systems include solid formulation of nanometric& micron size range with modified release profiles. These are either reservoir type or matrix type.
One of their most useful features is that they are easy to inject, either into tissue or intravenously. They are also easily adapted to other milieus, for inhalation as a dry powder, or topically in an appropriate vehicle.

Salient features

  • Modulate release rate
  • Suitable for both soluble & insoluble drugs
  • Protect active from harsh biological environment
  • Targeted delivery through ligand-conjugation & modified size/surface properties

Novel Solution Formulations

Novel Solution Formulations like micelles, complexation, cosolvency are used to improve solubility.

Salient features

  • Immediate action through injection
  • Increased oral bioavailability

Emulsion Formulation

Stable homogeneous biphasic systems as delivery systems for lipophilic drugs or to improve permeability of hydrophilic actives through various biological membranes.
Self emulsifying drug delivery systems (SEDDS) are delivery vehicles which further improves the stability of actives as well as formulation. These are either given as liquid filled capsules or solid dosage form.

Salient features

  • Improves oral & transdermal bioavailability
  • Improve specific membrane permeability
  • SEDDS reduces the dose volume & also improves stability of actives

Microneedles Patch

Array of multiple needles of micron size containing the active molecules embedded in the needles made up of polymers, simply applied by pressing on the skin. The active is released, when the needles are dissolved. These formulations deliver actives upto dermis region, thus localized delivery is possible. Also, transdermal permeability of active is increased as compared to patches/ gels/ ointment/ creams/ sprays as the active crosses the most impermeable part of skin, i.e. stratum corneum.

  • Because of increased permeation dose reduction
  • Efficacy improves because
    • Delivery is at the site of action
    • Bypasses First pass effect
    • Improved transdermal permeation
  • Freedom from irritating penetration enhancers or painful injections

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